The one-shot differs from AstraZeneca. Where I previously wrote about the AZ shot not affecting mRNA. The new one-shot jab being developed by other firms does affect mRNA and does genetically modify humans. This is because a different type of virus is used. This jab will continue to produce enzymes. In the past, there have been long term negative effects from different enzymes in the human body that are not a normal part of our evaluation. These negative effects are hard to measure except over the passage of time.
Note that RNA enzymes can replicate themselves. I don’t know if that is what the AZ jab might have released. Unlikely though.
For example:
An example of a dangerous enzyme is a prion (misfolded protein) one variant of which caused the CJD brain disease. The effects took a long time to mature in the body but with devastating effects.
[See https://en.wikipedia.org/wiki/Creutzfeldt%E2%80%93Jakob_disease and
https://en.wikipedia.org/wiki/Variant_Creutzfeldt%E2%80%93Jakob_disease]